Effect of Rosiglitazone on Myocardial Blood Flow Regulation in Type 2 Diabetes

Completed · Not applicable

Conditions studied: Type 2 Diabetes

In brief

The overall hypothesis to be tested is that increased insulin resistance contributes to abnormal cardiac blood flow regulation in type 2 diabetic patients, which can be reversed by 6 months treatment with rosiglitazone. The planned experimental approach will be to utilize nuclear medicine techniques to evaluate whether the administration of rosiglitazone for 6 months can reverse regional deficits in myocardial blood flow and glucose utilization in type 2 diabetes in a randomized double blind controlled study. These studies will help elucidate the potential of rosiglitazone to correct deficits of myocardial blood flow complicating diabetes with the overall aim being the eventual prevention of sudden cardiac death.

Key facts

Study ID

NCT00549874

Run by

University of Michigan

People needed

27

Starts

2002-02-01

Expected to finish

2006-11-01

Last updated by the study team

2007-11-09

Who can join

Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 2 diabetes
• 30-75 years of age
• less than 1% fluctuation in HbA1c over 3 months
• women must be on contraception
• HbA1c 6-9%
• willingness to sign approved consent form

You may not qualify if…

• Nursing mothers, pregnant women (excluded by a negative pregnancy test).
• Subjects requiring insulin therapy (>20 units/day) and can not be converted to sulfonylurea therapy without loss of diabetes control.
• Patients with a history of drug or alcohol dependence in the last 5 years
• Patients with pre-existing cardiovascular disease including coronary artery disease, heart attack, heart failure, abnormal heart rhythms, structural abnormalities and valve disease, peripheral vascular disease and uncontrolled high blood pressure.
• Patients with a history of high cholesterol requiring therapy.
• Patients with severe systemic disease other than diabetes which has as a recognized complication neuropathy
• Patients currently taking drugs which act on the blood vessels (for example for hypertension)
• Patients taking antidepressants, or other drugs or medications known to interfere with the uptake or metabolism of catecholamines (stress hormones)
• Patients with poor renal function or have significant liver disease
• Patients with a history of previous kidney, pancreas or cardiac transplantation.
• Patients with a history of "severe hypoglycemia" which required the assistance of a third party or ketoacidosis requiring hospital admission within the last 3 months.
• Patients with lung disease for example resulting from chronic obstructive airways disease.
• Patients with abnormal thyroid function tests.
• Patients having taken other systemic investigational drugs (especially for neuropathy) or initiating a new or experimental insulin delivery device within 3 months of starting the study.
• Patients with a history of allergic reactions to multiple drugs or biological products.
• Obese patients (BMI greater than 35).
• Patients who refuse to sign the informed consent.

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States
• University of Toledo - Health Campus — Toledo, Ohio, United States

Full record on ClinicalTrials.gov

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