Effect of Macrolide Antibiotics on Airway Inflammation in People With Chronic Obstructive Pulmonary Disease (COPD)

Completed · Has a placebo group

Conditions studied: Pulmonary Disease, Chronic Obstructive

In brief

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. Azithromycin, an antibiotic, may be beneficial at reducing the symptoms and severity of the disease. This study will analyze previously collected study data to evaluate the anti-inflammatory properties of azithromycin and determine how azithromycin affects the frequency and severity of COPD exacerbations.

Key facts

Study ID

NCT00549445

Run by

University of Alabama at Birmingham

People needed

53

Starts

2007-08-01

Expected to finish

2012-07-01

Last updated by the study team

2017-09-29

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participating in the COPD Network Macrolide study
• Clinical diagnosis of at least moderate COPD
• Cigarette consumption of 10 pack years or more

You may not qualify if…

• Diagnosis of asthma
• Predicted life expectancy of less than 3 years
• History of hypersensitivity to macrolide antibiotics
• Long-term kidney insufficiency
• Long-term liver insufficiency
• Prolonged QT interval
• Use of medications that may prolong the QT interval

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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