Use of Omega-3 Fatty Acids (Fish Oil) in Patients With Chronic Hepatitis C Infection

Withdrawn before enrolling · Not applicable · Has a placebo group

Conditions studied: Hepatitis C

In brief

Hepatitis C virus infection is the most common blood-borne infection in the United States and is a leading cause of chronic liver disease affecting 130 million people around the world. It is estimated that 1.6% of the US population may be affected by Hepatitis C infection. The only recommended treatment that has been approved for your condition is the use of interferon and ribavirin. In patients with chronic Hepatitis C, there tends to be an accumulation of fat in the liver. Fatty liver has been associated with failure of treatment. The accumulation of fat in the liver has been blamed on a particular type of fat called triglycerides. Fish oil, by reducing a type of fat called VLDL, can lower the triglyceride concentration by as much as 50 percent or more. This study seeks to determine if the administration of fish oil along with standard treatment to patients with Hepatitis C will increase the treatment response rates.

Key facts

Study ID

NCT00547716

Run by

University of Missouri, Kansas City

People needed

0

Starts

2009-06-01

Expected to finish

2012-08-01

Last updated by the study team

2017-01-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients > 18 years of age
• Patients with chronic hepatitis C infection
• Patients receiving interferon for treatment of hepatitis C

You may not qualify if…

• pregnant or lactating patients
• End stage target organ damage in diabetes mellitus: advanced renal failure (serum creatinine >2.0 mg/dl) with or without dialysis, severe neuropathy, advanced peripheral vascular disease.
• Anticipated life expectancy less than 2 years
• Co-existent etiologies for liver disease
• Alcohol consumption more than 30 g per day in men and more than 20 g per day in women.
• Patients on Omega-3 fatty acid supplementation or those patients who report eating oily fish such as salmon, albacore tuna, sardines, etc. twice a week or more frequently.

Where it is running

• Truman Medical Center — Kansas City, Missouri, United States
• Saint Luke's Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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