Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia

Stopped early · Not applicable · Has a placebo group

Conditions studied: Non Ulcer Dyspepsia

In brief

The purpose of this study is to determine if use of Nortriptyline will improve symptoms and quality of life in patients who have nonulcer dyspepsia.

Key facts

Study ID

NCT00547703

Run by

The Cleveland Clinic

People needed

5

Starts

2008-02-01

Expected to finish

2010-06-01

Last updated by the study team

2017-05-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and Women
• Ages 18-65
• Meet Rome III criteria for functional dyspepsia
• Endoscopy within 1 year

You may not qualify if…

• Allergic reaction or history of adverse events with Nortriptyline or tricyclic antidepressants
• Organic cause found on physical examination
• Organic cause found on lab work: Complete Blood Count, Comprehensive Metabolic Panel, Thyroid stimulating hormone, Tissue transglutaminase Immunoglobulin A
• Predominantly Gastroesophageal reflux symptoms
• Current Helicobacter pylori infection
• History of Peptic ulcer disease
• Non steroidal antiinflammatory use use > 2x/wk
• Pregnant or planning pregnancy
• History of major depression
• Abdominal surgery in the last year

Where it is running

• Cleveland Clinic Florida — Weston, Florida, United States

Full record on ClinicalTrials.gov

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