Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis

Completed · Phase 1

Conditions studied: Cystic Fibrosis

In brief

The purpose of this research study is to determine if multiple doses of two inhaled drugs will help Cystic Fibrosis patients whose lungs are infected with a bacteria called Burkholderia dolosa. The names of these drugs are tobramycin solution for inhalation and amiloride solution for inhalation. Currently, treating patients with Burkholderia dolosa infections is challenging because the bacteria is resistant to antibiotics. Therefore, researchers are looking for drugs which, when taken with an antibiotic, will help the antibiotic to work more effectively.

Key facts

Study ID

NCT00547053

Run by

Boston Children's Hospital

People needed

25

Starts

2006-12-01

Expected to finish

2011-01-01

Last updated by the study team

2011-05-13

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Cystic Fibrosis
• Two positive cultures for Burkholderia dolosa lung infection

You may not qualify if…

• Positive pregnancy test or currently breast feeding (if applicable)
• Known sensitivity to Amiloride

Where it is running

• Children's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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