Safety and Efficacy Study of Adjunctive Antiplatelet Therapy Prior to Primary PCI in Patients With STEMI

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Myocardial Infarction

In brief

Safety and efficacy of adjunctive antiplatelet therapy prior to primary percutaneous intervention (PCI) in patients with ST-Elevation Myocardial Infarction (STEMI)

Key facts

Study ID

NCT00546260

Run by

Alexion Pharmaceuticals, Inc.

People needed

70

Starts

2007-11-01

Expected to finish

2008-07-01

Last updated by the study team

2026-06-24

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Persistent ST elevation ≥ 1mm (≥ 0.1mV) in two contiguous limb leads OR ≥ 2 mm (≥ 0.2mV) in two contiguous precordial leads, AND chest pain ≥ 20 minutes with onset within 6 hours of hospital presentation.

You may not qualify if…

• Cardiogenic shock (systolic blood pressure < 90 mm Hg requiring vasopressor or hemodynamic support)
• Uncontrolled hypertension defined as any measured systolic blood pressure (SBP) > 180 mm Hg or diastolic blood pressure (DBP) ≥ 110 mm Hg after the time -- History or symptoms of a congenital or acquired bleeding disorder or vascular malformation.
• Recent gastrointestinal bleeding within the last 30 days.
• Known thrombocytopenia (platelet count < 100,000/mm3).
• Any treatment with a fibrinolytic agent within the last 7 days.

Where it is running

• Tallahassee Memorial Medical Center — Tallahassee, Florida, United States
• Iowa Heart Center — Des Moines, Iowa, United States
• University of Kentucky Hospital, Gill Heart Center — Lexington, Kentucky, United States
• Maine Medical Center — Portland, Maine, United States
• Washington Adventist Hospital — Takoma Park, Maryland, United States
• Henry Ford Hospital — Detroit, Michigan, United States
• Genesys Regional Medical Center — Grand Blanc, Michigan, United States
• St. Joseph Mercy - Oakland — Pontiac, Michigan, United States
• William Beaumont Hospital — Royal Oak, Michigan, United States
• William Beaumont Hospital - Troy Cardiology — Troy, Michigan, United States
• Lindner Clinical Trial Center — Cincinnati, Ohio, United States
• Geisinger Medical Center — Danville, Pennsylvania, United States
• The Heart Center — Kingsport, Tennessee, United States
• Foothills Hospital — Calgary, Alberta, Canada
• Royal Alexandria Hospital — Edmonton, Alberta, Canada
• University of Alberta Hospital — Edmonton, Alberta, Canada
• Vancouver General Hospital — Vancouver, British Columbia, Canada
• St. Paul's Hospital — Vancouver, British Columbia, Canada
• Victoria Heart Institute, Royal Jubilee Hospital — Victoria, British Columbia, Canada
• Atlantic Health Services — Saint John, New Brunswick, Canada
• General Hospital - Heath Sciences Centre — St. John's, Newfoundland and Labrador, Canada
• Queen Elizabeth II Health Sciences Centre — Halifax, Nova Scotia, Canada
• Hamilton Health Sciences — Hamilton, Ontario, Canada
• London Health Sciences — London, Ontario, Canada
• Trillium Health Centre - Mississaugua — Mississauga, Ontario, Canada

Full record on ClinicalTrials.gov

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