Infant Immune Response to Bacterial Infection
Completed
Conditions studied: Prematurity, Histologic Chorioamnionitis
In brief
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants. The blood samples will be taken from both male infants who were carried to term and male infants who were born prematurely, and genetic studies will compare these blood samples to samples drawn from healthy adult male volunteers. The study is designed to look at the ways in which the immune systems of newborn infants respond to bacterial infection. Participants in this study will be pregnant Chinese women admitted to the labor ward of the Prince of Wales Hospital (Sha Tin district of New Territories, Hong Kong SAR) for normal spontaneous delivery. Those with known blood-borne infectious diseases such as HIV and hepatitis B will be excluded from this study. Cord blood and placenta samples will be collected after the completion of delivery. The samples collected for this study will be restricted to male newborns. A comparison group of blood samples will be drawn from healthy male adults between 25 and 35 years of age....
Key facts
- Study ID
- NCT00546195
- Run by
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- People needed
- 45
- Starts
- 2007-10-15
- Expected to finish
- 2011-03-29
- Last updated by the study team
- 2017-07-02
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Patient diagnosed with known infectious diseases such as HIV and HBV positive cases (blood precautions).
- Patients are incompetent to consent such as being mentally retarded or mentally ill and without an impairment of judgment at the time of consenting.
- Patients who do not consent.
Where it is running
- National Institute of Child Health and Human Development (NICHD), 9000 Rockville — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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