A Study Of Tanezumab as Add-On Therapy to Opioid Medication In Patients With Pain Due To Cancer That Has Spread To Bone

Completed · Phase 2 · Has a placebo group

Conditions studied: Neoplasm Metastasis, Palliative Care

In brief

The purpose of this study is to investigate the safety and efficacy of tanezumab in combination with opioids in treating pain due to cancer that has spread to bone.

Key facts

Study ID

NCT00545129

Run by

Pfizer

People needed

59

Starts

2009-04-29

Expected to finish

2012-02-07

Last updated by the study team

2021-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Prostate cancer, breast cancer, renal cell carcinoma or multiple myeloma that has spread to bone, causing moderate to severe bone pain.
• Requires daily opioid medication

You may not qualify if…

• Patients who do not have bone pain caused by cancer are not eligible for the study.
• Patients who started chemotherapy less than 4 weeks ago, or who completed radiotherapy less than 4 weeks ago, are not eligible.
• Known history or evidence of osteoarthritis. History of significant trauma to a major joint within 1 year prior to Screening.
• Known history of rheumatoid arthritis.

Where it is running

• Medical University of South Carolina, Department of Urology — Charleston, South Carolina, United States
• MUSC Department of Radiology — Charleston, South Carolina, United States
• MUSC Investigational Pharmacy — Charleston, South Carolina, United States
• MUSC Urology Ambulatory Care — Charleston, South Carolina, United States
• Huntsman Cancer Institute at the University of Utah — Salt Lake City, Utah, United States
• Landeskrankenhaus Graz - Universitaetsklinik fuer Orthopaedie und Orthopaedische Chirurgie — Graz, Austria
• Krankenhaus der Elisabethinen Linz, Institut fuer Anaesthesiologie und Intensivmedizin — Linz, Austria
• Nuhr Zentrum — Senftenberg, Austria
• Clinic of Oncology — Banja Luka, Bosnia and Herzegovina
• Institute of Oncology, University Clinical Center Sarajevo — Sarajevo, Bosnia and Herzegovina
• General Hospital Varazdin — Varaždin, Croatia
• Institut Gustave Roussy — Villejuif, France
• Fovarosi Onkormanyzat Peterfy Sandor Utcai Korhaz - Fajdalom Ambulancia — Budapest, Hungary
• Fovarosi Onkormanyzat Jahn Ferenc Del-pesti Korhaz - Fajdalom Ambulancia — Budapest, Hungary
• Fejer Megyei Szt. Gyorgy Korhaz - Rendelointezet/Aneszteziologiai es Intenziv Betegellato Osztaly — Székesfehérvár, Hungary
• Shri Siddhivinayak Ganpati Cancer Hospital — Miraj, Maharashtra, India
• Central India Cancer Research Institute — Nagpur, Maharashtra, India
• Shatabdi Superspeciality Hospital — Nashik, Maharashtra, India
• Chhatrapati Shahuji Maharaj Medical University — Lucknow, Uttar Pradesh, India
• Rajiv Gandhi Cancer Institute and Research Centre, — New Delhi, India
• 10th Department, Latvian Oncological Centre / Riga Eastern Clinical University Hospital — Riga, Latvia
• Centro de Cancer del Centro Medico ABC — Mexico City, Mexico City, Mexico
• Hospital Nacional Guillermo Almenara Irigoyen — Lima, LIMA L13, Peru
• Oncocare — Lima, Peru
• Niepubliczny Zaklad Opieki Zdrowotnej — Bydgoszcz, Poland

Full record on ClinicalTrials.gov

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