Using Magnetic Resonance Imaging to Predict People Who Are Likely to Develop Flash Pulmonary Edema (The PREDICT Study)

Completed

Conditions studied: Heart Failure, Congestive

In brief

Flash pulmonary edema is a sudden, abnormal build-up of fluid in the lungs. It is usually caused by heart failure and can be life threatening. The purpose of this study is to determine if a new form of magnetic resonance imaging (MRI) can identify abnormal blood flow to the lungs and predict increased risk of developing flash pulmonary edema among older adults.

Key facts

Study ID

NCT00542503

Run by

Wake Forest University Health Sciences

People needed

579

Starts

2007-06-01

Expected to finish

2013-12-01

Last updated by the study team

2021-09-09

Who can join

Age: 55 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must be diagnosed with one of the following conditions:
• Diabetes with a fasting glucose level greater than or equal to 126 mg/dl and has been receiving treatment for more than 5 years
• High blood pressure with a history of a systolic blood pressure level greater than 140 mm Hg and a diastolic blood pressure level greater than 85 mm Hg while on medication
• Coronary artery disease

You may not qualify if…

• Prior heart attack encompassing greater than 5% of the left ventricular mass (total MB greater than 3 or Troponin I greater than 2)
• Heart attack, acute coronary syndrome (ACS), or angina within the 1 year prior to study entry
• Medical inability to use any cardiovascular magnetic resonance device (e.g., implanted electronic devices, intracranial metal, claustrophobia, closed angle glaucoma)
• Medically unable to receive dobutamine
• 3-vessel or left main coronary artery disease
• Moderate to severe valvular heart disease
• Left ventricular ejection fraction (LVEF) less than 25%
• History of pulmonary edema
• Serum creatinine level greater than 2.4 mg/dL or estimated glomerular filtration rate (eGFR) less than 30 mL/min
• Use of an investigational drug or device within the 30 days prior to study entry
• Diagnosed with any systemic disease, including cancer, with a reduced life expectancy of less than 12 months
• Chronic atrial fibrillation

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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