Absorptive Clearance in the Cystic Fibrosis Airway
Completed · Not applicable
Conditions studied: Cystic Fibrosis
In brief
The objective of this overall project is to develop a new aerosol-based technique for quantifying liquid absorption in the airways of subjects with cystic fibrosis(CF) that can be used to help develop new therapies. In CF, mutations in the CF gene result in dysfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ion channel on the cells that line the airway epithelium, causing improper fluxes of ions such as sodium, chloride, and bicarbonate. The so called "low volume" hypothesis of CF pathogenesis contends that abnormal absorption of ions from the airways causes excessive absorption of liquid, resulting in an airway surface liquid layer that is dehydrated and difficult to clear. Here we are measuring the absorption rate of a radiolabeled small molecule (DTPA) from the lungs of cystic fibrosis patients and healthy controls. We hypothesize that the molecule will absorb more quickly in cystic fibrosis patients. Further studies will be performed to determine if DTPA absorption is related to liquid absorption in the airways.
Key facts
- Study ID
- NCT00541190
- Run by
- University of Pittsburgh
- People needed
- 21
- Starts
- 2007-10-01
- Expected to finish
- 2008-04-01
- Last updated by the study team
- 2017-08-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Cystic fibrosis subjects and healthy controls
- Age ≥ 18 years
- Diagnosis of cystic fibrosis as determined by sweat test or genotype and clinical symptoms (CF subjects)
- Clinically stable as determined by the investigator (pulmonologist)
You may not qualify if…
- Reactive airways disease
- Tobacco smokers (regular smoking within 6 months of enrollment)
- Positive urine pregnancy test on the day of testing
- FEV1p value of < 50%
- SaO2 < 92%, or if they require supplemental oxygen.
- Subjects performing other radioisotope studies within the last 2 weeks will be excluded.
- Healthy subjects with any history of lung disease will be excluded.
- Women currently breastfeeding
- Subjects not willing to stop treatments with inhaled hypertonic saline for 48 hours in advance of the study.
Where it is running
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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