A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Completed · Phase 4

Conditions studied: Paroxysmal Atrial Fibrillation

In brief

The purpose of this study is to compare radiofrequency catheter ablation and antiarrhythmic drug treatment for the maintenance of sinus rhythm in paroxysmal atrial fibrillation patients.

Key facts

Study ID

NCT00540787

Run by

Biosense Webster, Inc.

People needed

112

Starts

2003-08-01

Expected to finish

2006-06-01

Last updated by the study team

2025-02-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Paroxysmal atrial fibrillation for at least 6 months with at least 2 symptomatic episodes (patient history) during the previous month
• Atrial fibrillation (patient history or echocardiogram documented) resistant to at least one antiarrhythmic drug of Class I or III
• Documentation of at least one episode of atrial fibrillation on 12-lead echocardiogram or Holter Monitor

You may not qualify if…

• Contraindications to more than 2 antiarrhythmic drugs of different classes, or to oral anticoagulants
• History of any previous ablation for atrial fibrillation
• Intracardiac thrombus
• Atrial fibrillation due to reversible cause
• Pregnancy
• Contraindication to stopping oral anticoagulation (for example as a result of a mechanical cardiac valve)

Where it is running

• University of Alabama, Birmingham — Birmingham, Alabama, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Mid-Ohio Cardiology — Columbus, Ohio, United States
• Hôpital Haut Lèvêque — Pessac, Paris, France
• Hopital Lariboisiere — Paris, France
• Hopital Cantonal de Geneve — Geneva, Switzerland

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.