Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

Completed · Phase 1/Phase 2

Conditions studied: Brain Injury, Intracranial Pressure

In brief

The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.

Key facts

Study ID

NCT00538616

Run by

Carmelo Graffagnino

People needed

8

Starts

2008-01-01

Expected to finish

2010-04-01

Last updated by the study team

2013-04-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• primary diagnosis of Traumatic Brain Injury (TBI), Subarachnoid Hemorrhage (SAH),Intracranial Hemorrhage (ICH), stroke
• Must require (be on) mechanical ventilation
• must require (have in place) intracranial pressure (ICP) monitoring
• must require (be receiving) continuous IV sedation

You may not qualify if…

• Bleeding diathesis
• Glasgow Coma Scale (GCS) < 5 with fixed pupils
• Pregnant
• elevated ICP that requires deep sedation
• pulmonary instability
• Hx of Ethanol(ETOH) abuse that requires current benzodiazepine treatment for delirium - allergy to propofol or precedex
• status epilepticus
• current neuromuscular blockade

Where it is running

• Duke University — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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