Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic Leukemia

Completed · Not applicable

Conditions studied: Adult Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia

In brief

This clinical trial is studying the side effects of Erwinia asparaginase and what happens to the drug in the body in treating young patients with acute lymphoblastic leukemia who are allergic to PEG-asparaginase. Drugs used in chemotherapy, such as Erwinia asparaginase, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.

Key facts

Study ID

NCT00537030

Run by

Children's Oncology Group

People needed

59

Starts

2008-02-11

Last updated by the study team

2019-07-09

Who can join

Age: 1 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of acute lymphoblastic leukemia
• Concurrently enrolled on a frontline Children's Oncology Group treatment trial (i.e., COG-AALL0232 or COG-AALL0531, COG-AALL0331, or COG-AALL0434) at a participating institution
• Must have 1 or more courses of asparaginase remaining to be administered on the treatment protocol
• Must have had a grade ? 2 hypersensitivity reaction to PEG-asparaginase
• No history of pancreatitis ? grade 2
• No prior Erwinia asparaginase

Where it is running

• University of Alabama at Birmingham Cancer Center — Birmingham, Alabama, United States
• Phoenix Childrens Hospital — Phoenix, Arizona, United States
• Kaiser Permanente Downey Medical Center — Downey, California, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• Children's Hospital Central California — Madera, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Rady Children's Hospital - San Diego — San Diego, California, United States
• UCSF Medical Center-Mount Zion — San Francisco, California, United States
• UCSF Medical Center-Parnassus — San Francisco, California, United States
• Harbor-University of California at Los Angeles Medical Center — Torrance, California, United States
• Children's Hospital Colorado — Aurora, Colorado, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Nemours Children's Clinic-Jacksonville — Jacksonville, Florida, United States
• Johns Hopkins All Children's Hospital — St. Petersburg, Florida, United States
• Lurie Children's Hospital-Chicago — Chicago, Illinois, United States
• Advocate Christ Medical Center — Oak Lawn, Illinois, United States
• Advocate Children's Hospital-Oak Lawn — Oak Lawn, Illinois, United States
• Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
• Norton Children's Hospital — Louisville, Kentucky, United States
• Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland, United States
• Spectrum Health at Butterworth Campus — Grand Rapids, Michigan, United States
• Kalamazoo Center for Medical Studies — Kalamazoo, Michigan, United States
• Children's Hospitals and Clinics of Minnesota - Minneapolis — Minneapolis, Minnesota, United States
• University of Minnesota/Masonic Cancer Center — Minneapolis, Minnesota, United States
• The Childrens Mercy Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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