Physical Inactivity and Insulin Resistance in Skeletal Muscle.

Withdrawn before enrolling · Not applicable

Conditions studied: Metabolic Syndrome X, Insulin Resistance, Hypertension, Hypercholesterolemia, Obesity

In brief

The purpose of this study is to determine how a decline in physical activity acutely leads to a decrease in insulin sensitivity in skeletal muscle. The hypothesis is that the loss of insulin sensitivity following physical inactivity is caused by a rapid reduction in skeletal muscle mitochondrial oxidative capacity.

Key facts

Study ID

NCT00536211

Run by

University of Kansas Medical Center

People needed

0

Starts

2009-06-01

Expected to finish

2011-12-01

Last updated by the study team

2021-05-04

Who can join

Age: 20 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Selection of inclusion for Metabolic Syndrome Subjects :
• Sedentary metabolic syndrome subjects will be 20-55 y of age, overweight to Class I or II obese (BMI 25-39 kg/m2) men and women, who have a fasting glucose of 100 to 125 mg/dl, and at least 2 of 4 other characteristics of the metabolic syndrome which are the following: waist circumference greater than 102 cm in men and 88 cm in women, serum triglyceride concentration greater than 150 mg/dl, HDL-C concentration greater than 40 mg/dl in men and 50 mg/dl in women, and blood pressure greater than 130/85 mmHG.
• Selection for inclusion for Endurance Athlete Subjects:
• Subjects who report training (running and/or biking) greater than 30 min a day, 4 days a week for at least 1 year will be included. Final inclusion criteria will be a VO2max of greater than 55 ml/kg/min.
• To take part in the study, Women must currently be taking birth control or be postmenopausal.

You may not qualify if…

• Subjects will be excluded from the study if they have or are:
• Diagnosed cardiovascular disease or diabetes or disease symptoms that could alter their ability to perform exercise, fasting blood glucose of greater than 126 mg/dl, smokers, taking any medications or supplements (e.g., statins, fibrates, metformin, thiazolidinediones, anti-hypertensives (ACE-inhibitors and angiotensin blockers) which could affect blood lipids or insulin sensitivity.
• Women who are pregnant or plan to become pregnant during the duration of the study For the Metabolic Syndrome subjects only individuals exercising regularly (more than one 30 min session per week) or have a physically active lifestyle (>8,000 daily steps as measured by a pedometer) will be excluded.
• Individuals with an orthopedic limitations for walking. Allergies to drugs used in the study. Past or current liver and/or kidney problems of any nature.

Where it is running

• Harry S. Truman Memorial Veterans' Hospital — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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