Speckle Tracking Imaging in Patients With Low Ejection Fraction Aortic Stenosis (SPArKLE-AS)

Stopped early

Conditions studied: Aortic Stenosis

In brief

In patients with aortic stenosis and low ejection fraction, how can we predict who will recover their ejection fraction after aortic valve replacement? We plan to observe 50 patients with Low EF aortic stenosis and perform serial echocardiograms pre and post-aortic valve replacement and analyze regional wall motion contractility with a new software application called speckle tracking imaging.

Key facts

Study ID

NCT00535899

Run by

The Cleveland Clinic

People needed

50

Starts

2007-09-01

Last updated by the study team

2008-05-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Severe aortic stenosis with ejection fraction less than 40% that is schedule to undergo aortic valve replacement

You may not qualify if…

• Creatinine > 2
• More than moderate mitral, tricuspid, or aortic regurgitation.
• Endocarditis
• Emergent surgery
• Prior sternotimy

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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