Study to Determine if Serum BNP Levels Are Elevated in Pregnant Women With Pre-Eclampsia
Completed
Conditions studied: Preeclampsia
In brief
Preeclampsia is a common disease state occurring in the third trimester of pregnancy, with an incidence of approximately 5-10% in the US. Hypertension (high blood pressure), a primary symptom of pre-eclampsia, may be present in women who were hypertensive prior to becoming pregnant.B-type (also known as brain) natriuretic peptide (BNP) is known to be made and released from the heart ventricles when the heart is strained. There is also evidence that BNP is secreted in the placenta, and may increase in preeclampsia and chronic hypertension in pregnancy.The purpose of the study is to determine if a maternal blood sample analyzed for the quantity of BNP is helpful in differentiating between pre-eclampsia and chronic high blood pressure.
Key facts
- Study ID
- NCT00533871
- Run by
- Ohio State University
- People needed
- 61
- Starts
- 2003-02-01
- Expected to finish
- 2005-06-01
- Last updated by the study team
- 2007-09-24
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Pregnant women age 18 or older at 34 or more weeks of pregnancy
- Control arm:normal blood pressure during pregnancy
- Chronic HTN arm: known to have HTN predating this gestation
- Pre-eclampsia arm:meet ACOG diagnostic criteria for pre-eclampsia this pregnancy and present to labor and delivery for evaluation and/ or treatment
You may not qualify if…
- minors, prisoners,unable to provide consent
- multiple gestation
- currently in labor
- Control arm:presence of hypertension, a history of gestational hypertension, current therapy with an anti-hypertensive medication, any history of congestive heart failure
- Chronic HTN arm:evidence of superimposed preeclampsia at the time of enrollment (headache, proteinuria, peripheral edema, or visual changes), any history of congestive heart failure
- Pre-eclampsia arm:history of congestive heart failure, pretreatment with anti-hypertensive medication
Where it is running
- The Ohio State University — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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