4-Dimensional CT Derived Ventilation Versus SPECT Aerosol Ventilation in Patients With Thoracic Malignancies

Completed · Phase 2

Conditions studied: Esophageal Cancer, Lung Cancer

In brief

Objectives: Primary Objective: 1\. To determine the correlation between 4-dimensional computed tomography (4D CT) derived ventilation and single photon emission tomography (SPECT) aerosol Tc-99m determined ventilation. Secondary Objective: 1. To evaluate the reproducibility of the 4D CT derived ventilation and to obtain an estimate of the variance in a single setting. 2. To assess the correlation between hypoperfused and hypoventilated pulmonary regions in patients with thoracic malignancies. 3. To investigate the effect of continuous positive airway pressure (CPAP) on ventilation and tumor motion.

Key facts

Study ID

NCT00531180

Run by

M.D. Anderson Cancer Center

People needed

31

Starts

2007-08-21

Expected to finish

2018-09-21

Last updated by the study team

2018-10-25

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with pathologic diagnosis of esophagus or lung cancer (Stage I through IV).
• Patients must be able to lie flat for the duration of the treatment planning sessions.
• Patients must sign informed consent.
• Patients who are scheduled to receive radiation therapy.
• A cohort of 6 lung cancer patients whose primary tumors move greater than 1 cm will be recruited (CPAP cohort).

You may not qualify if…

• Significant pleural effusion as evaluated by the attending Radiation Oncologist is excluded.
• Women of childbearing potential (A woman of child-bearing potential is a sexually mature woman who has not undergone a hysterectomy or who has not been naturally postmenopausal for at least 24 consecutive months [i.e., who has had menses at any time in the preceding 24 consecutive months]) and male participants must practice effective contraception (oral, injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive with spermicide; or vasectomized partner) throughout the study.
• Patients with severe COPD or asthma will be excluded from the CPAP cohort.

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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