Study of Phenobarbital Inhibition of Catamenial Epilepsy
Withdrawn before enrolling · Not applicable · Has a placebo group
Conditions studied: Epilepsy
In brief
The purpose of this study is to test the effectiveness of low-dose Phenobarbital on the treatment of catamenial epilepsy. We propose that since the catamenial seizures are associated with the reduction in levels of GABA-enhancing allopregnanolone, short-term replacement with the GABAR-enhancing agent Phenobarbital will reduce the incidence of catamenial seizures.
Key facts
- Study ID
- NCT00530413
- Run by
- University of Toledo Health Science Campus
- People needed
- 0
- Starts
- 2007-03-01
- Last updated by the study team
- 2014-12-10
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Adult female patients seeking medical attention for seizures
- Regular menstrual cycles
- At least 2 seizures per month
- Must be on at least one form of birth control other than abstinence
- Must be on a stable anticonvulsant regimen of at least one and not exceeding three anticonvulsants, and not be using any perimenstrual seizure medications of hormone preparations
- If taking benzodiazepines for therapeutic purposes, must be on a stable regular dose
- Must be willing to take at least 400mcg of folic acid a day while in the study
- Must be able to detect, count or record seizures
You may not qualify if…
- Can not be pregnant or trying to become pregnant
- Can not have used hormonal birth control methods for at least 3 months prior to enrollment
- Can not have an allergy to Phenobarbital
- Can not have a history of non-epileptic seizures
- Can not have a know liver dysfunction or history of chronic hepatitis
- Can not have a history of neurological disorder or history of status epilepticus in the preceding year
- Can not ahve a physical or psychiatric condition which in the PIs opinion could compromise her ability to participate
Where it is running
- University of Toledo, Health Science Campus — Toledo, Ohio, United States
Full record on ClinicalTrials.gov
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