Ganciclovir by Infusion and by Mouth in Treating Patients With Cytomegalovirus After Donor Bone Marrow Transplant
Completed · Phase 2
Conditions studied: Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Leukemia, Lymphoma, Multiple Myeloma, MDS, Myelodysplastic/Myeloproliferative Diseases
In brief
RATIONALE: Antiviral drugs, such as ganciclovir, act against viruses. Giving ganciclovir by infusion and then by mouth may be effective treatment for cytomegalovirus that has become active after donor bone marrow transplant. PURPOSE: This phase II trial is studying how well giving ganciclovir by infusion and by mouth works in treating patients with cytomegalovirus after donor bone marrow transplant.
Key facts
- Study ID
- NCT00530218
- Run by
- City of Hope Medical Center
- People needed
- 61
- Starts
- 1999-03-01
- Expected to finish
- 2010-02-01
- Last updated by the study team
- 2017-12-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- DISEASE CHARACTERISTICS:
- Undergoing allogeneic transplantation, including unrelated donor bone marrow transplantation (BMT) and/or allogeneic donor leukocyte infusion, for any indication
- Patients or their donors must have had a positive pre-BMT cytomegalovirus (CMV) antibody titer as measured by enzyme-linked immunosorbent assay (ELISA)
- PATIENT CHARACTERISTICS:
- Able to comply with study requirements
You may not qualify if…
- Signs or symptoms of documented CMV infection, including any positive CMV culture from any site and/or any suspected or documented CMV-associated clinical syndrome, at the time of study entry
- History of symptomatic CMV-associated clinical syndrome
- PRIOR CONCURRENT THERAPY:
- Receiving concurrent investigational antiviral agents
- PATIENT CHARACTERISTICS:
- History of hypersensitivity to ganciclovir or acyclovir
Where it is running
- City of Hope National Medical Center — Duarte, California, United States
Full record on ClinicalTrials.gov
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