Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity

Completed

Conditions studied: Emphysema

In brief

Although single breath helium (He) dilution measurement (VASB) is currently used in pulmonary function laboratories to assess functional alveolar volume and diffusing capacity for carbon monoxide, the extent to which VASB reflects ventilatory and thoracic volume has not been prospectively determined in emphysema. We hypothesized that VASB underestimates rebreathe helium dilution volume (VARB), and plethysmographic volume (VApleth) as clinical and physiologic severity of emphysema increases.

Key facts

Study ID

NCT00528944

Run by

Columbia University

People needed

73

Starts

2006-01-01

Expected to finish

2008-07-01

Last updated by the study team

2015-07-07

Who can join

Age: 18 and older, up to 81. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All outpatients between the ages of 18 and 81 years referred to the Columbia University Medical Center Pulmonary Diagnostic Unit between 1/18/06 and 7/30/07 for full pulmonary function evaluation, and with an obstructive ventilatory defect on spirometry, were considered eligible.

You may not qualify if…

• Patients who did not want to undergo the re-breathe diffusing capacity testing
• Patients who could not give informed consent;and
• Patients who were too physically compromised to undergo full testing including the re-breathe maneuver as deemed by our technicians.

Where it is running

• Columbia University Cardiopulmonary, Sleep and Ventilatory Disorders Center — New York, New York, United States

Full record on ClinicalTrials.gov

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