Proof of Concept Study of Cognitive Improvement in Patients With Schizophrenia

Completed · Phase 2

Conditions studied: Schizophrenia

In brief

The purpose of this study is to demonstrate that AZD3480 improves cognition in patients with stable schizophrenia who are being treated with an atypical antipsychotic and who are active cigarette smokers, to assess the safety and tolerability of AZD3480 and to define the optimal dose(s) to be used in future trials.

Key facts

Study ID

NCT00528905

Run by

AstraZeneca

People needed

400

Starts

2007-08-01

Expected to finish

2008-11-01

Last updated by the study team

2008-11-25

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of schizophrenia
• Outpatient at the time of screening and randomization
• Stable housing defined as having a place to live in the community (ie, not in a hospital or nursing home)
• Active cigarette smoking (10 or more cigarettes per day

You may not qualify if…

• Any significant psychiatric or neurological disease other than schizophrenia, or current diagnosis of major depressive disorder
• Known or suspected drug or alcohol abuse within the 6 months or urine toxicology test positive for illegal or non-prescribed substances
• Impaired vision and/or hearing making cognitive testing difficult

Where it is running

• Research Site — Anaheim, California, United States
• Research Site — Cerritos, California, United States
• Research Site — Costa Mesa, California, United States
• Research Site — Escondido, California, United States
• Research Site — Garden Grove, California, United States
• Research Site — Long Beach, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — Oceanside, California, United States
• Research Site — Pasadena, California, United States
• Research Site — Pico Rivera, California, United States
• Research Site — San Diego, California, United States
• Research Site — Santa Ana, California, United States
• Research Site — New Britain, Connecticut, United States
• Research Site — New Haven, Connecticut, United States
• Research Site — Washington D.C., District of Columbia, United States
• Research Site — Boca Raton, Florida, United States
• Research Site — Coral Gables, Florida, United States
• Research Site — North Miami, Florida, United States
• Research Site — Orlando, Florida, United States
• Research Site — Tampa, Florida, United States
• Research Site — Atlanta, Georgia, United States
• Research Site — Augusta, Georgia, United States
• Research Site — Marietta, Georgia, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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