Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation

Completed

Conditions studied: Bronchiolitis Obliterans Syndrome

In brief

A major source of graft failure and dysfunction in lung transplantation is known to be bronchiolitis obliterans (BO)and its clinical correlate called bronchiolitis obliterans syndrome(BOS). In fact, BOS is the leading cause of death in lung recipients beyond one year post transplant. Currently, our ability to assess lung injury after transplant is less than ideal. The purpose of this study is to use new computerized tomography(CT) technology, specifically , 64 bit acquisition, to detect and predict the onset of lung injuries, with the hope of finding better therapies that currently exist.

Key facts

Study ID

NCT00528853

Run by

University of Chicago

People needed

10

Starts

2007-08-01

Expected to finish

2009-12-01

Last updated by the study team

2016-08-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Lung transplant patients who are at least 18 years of age.
• All patients must be able to give written informed consent.

You may not qualify if…

• Lung transplant patients who are unable to undergo a CT Scan.
• Lung transplant patients who are unable to give informed consent.

Where it is running

• The University of Chicago Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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