Pilot Study to Identify the Influence of Genetic Profile Aberrations on Patients With Recurrent Hernias

Stopped early

Conditions studied: Pathological Processes

In brief

The aim of this study is to compare collagen composition in the skin and fascia of patients with recurrent or incisional hernias versus normal controls. We will identify potential genes responsible for genetic alterations in collagen deposition by using gene chip analysis of the tissue obtained and comparing the hernia group versus controls. The ultimate goal of this study is to identify target genes which may help us eventually predict which patients are at risk for developing post-operative hernias.

Key facts

Study ID

NCT00527670

Run by

University of Missouri-Columbia

People needed

41

Starts

2007-08-01

Expected to finish

2010-11-01

Last updated by the study team

2016-08-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Hernia Group: Diagnosis of ventral or incisional hernia.
• Control Group: appendicitis, symptomatic cholelithiasis or cholecystitis, adrenal disease necessitating adrenalectomy.
• Scheduled for an appropriate laparoscopic repair of above diagnosis.
• Females only: Not pregnant.

You may not qualify if…

• Steroid use
• Severe COPD or pulmonary disorders
• History of a connective tissue disorder
• Presentation for surgery with a diagnosis other than those listed above in inclusion criteria

Where it is running

• University of Missouri Hospital and Clinics — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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