Docetaxel and Prednisone With or Without Cediranib in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy

Stopped early · Phase 2

Conditions studied: Adenocarcinoma of the Prostate, Stage IV Prostate Cancer

In brief

This randomized phase II trial is studying how well giving docetaxel and prednisone together with or without cediranib works in treating patients with metastatic prostate cancer that did not respond to hormone therapy. Drugs used in chemotherapy, such as docetaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cediranib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving docetaxel together with prednisone, with or without cediranib, may kill more tumor cells.

Key facts

Study ID

NCT00527124

Run by

National Cancer Institute (NCI)

People needed

57

Starts

2007-11-01

Expected to finish

2013-11-01

Last updated by the study team

2018-08-09

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Clinical/radiologic metastases with objective evidence of disease progression by imaging or by rising prostate-specific antigen (PSA) despite androgen deprivation therapy
• Rising PSA must be determined based on a rising trend with 2 successive elevations at a minimum interval of 1 week
• Meets 1 of the following criteria: Measurable disease, with any level of PSA, at least 1 unidimensionally measurable lesion (longest diameter to be recorded) >= 20 mm by conventional techniques or >= 10 mm by spiral CT scan, nonmeasurable disease, PSA >= 5 ng/mL OR new areas of bony metastases on bone scan
• Castrate levels of testosterone < 50 ng/dL must be maintained and documented
• Luteinizing hormone-releasing hormone (LHRH) agonist therapy must be continued, if required to maintain castrate levels of testosterone
• Total bilirubin normal
• Patients with radiological evidence of stable brain metastases are eligible provided they are asymptomatic and do not require corticosteroids or have been treated with corticosteroids and show clinical and radiological evidence of stabilization at least 10 days after discontinuation of steroids
• ECOG performance status (PS) =< 2 or Karnofsky PS 60-100%
• Life expectancy > 12 weeks
• Leukocytes >= 3,000/mcL
• Absolute neutrophil count >= 1,500/mcL
• Platelet count >= 100,000/mcL
• Histologically confirmed adenocarcinoma of the prostate
• AST and ALT =< 2.5 times upper limit of normal
• Creatinine normal OR creatinine clearance >= 60 mL/min
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Proteinuria =< 1+ and urine protein:creatinine ratio =< 1.0 OR 24-hour urine protein < 1,000 mg
• Peripheral neuropathy >= grade 2
• Uncontrolled intercurrent illness including, but not limited to, any of the following: ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, psychiatric illness/social situations that would limit compliance with study requirements
• Congestive heart failure, second or third degree heart block, or recent myocardial infarction within the past 6 months
• QTc prolongation > 500 msec OR other ECG abnormality noted within 14 days of treatment
• New York Heart Association class III or IV cardiac disease; Class II disease controlled with treatment and monitoring allowed
• History of poorly controlled hypertension (e.g., resting blood pressure > 150/90 mm Hg with or without hypertensive therapy)

Where it is running

• Barbara Ann Karmanos Cancer Institute — Detroit, Michigan, United States
• Wayne State University — Detroit, Michigan, United States
• M D Anderson Cancer Center — Houston, Texas, United States
• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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