PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28
Completed · Phase 1
Conditions studied: Neurocysticercosis, Healthy
In brief
The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people.
Key facts
- Study ID
- NCT00526916
- Run by
- National Institute of Mental Health (NIMH)
- People needed
- 18
- Starts
- 2007-09-04
- Expected to finish
- 2014-09-05
- Last updated by the study team
- 2019-12-12
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- COMMON TO ALL SUBJECTS:
- Current psychiatric illness, substance abuse or severe systemic disease based on history and physical exam.
- ECG with clinically significant abnormalities. Any existing physical exam and ECG within one year will be reviewed and if none already exists in the chart, these will be obtained and reviewed.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual guideline of RSC.
- Pregnancy or breast feeding.
- Claustrophobia.
- Positive HIV test.
- Cannot lie on back for a few hours for the PET scans.
- Presence of ferromagnetic metal in the body or heart pacemaker.
- ADDITIONAL EXCLUSION CRITERIA FOR PATIENTS:
- Medically unstable.
- Seizures are not well controlled with medications.
- A history of brain disease other than neurocysticercosis.
- Laboratory tests with clinically significant abnormalities unrelated to neurocysticercosis or its treatment.
- ADDITIONAL EXCLUSION CRITERIA FOR HEALTHY SUBJECTS:
- Laboratory tests with clinically significant abnormalities.
- A history of brain disease.
- The usage of nonsteroidal and other anti-inflammatory medications is not an exclusion criterion.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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