Study of Mood Effects of Varenicline (Chantix) in Depressed Outpatient Smokers

Completed · Not applicable

Conditions studied: Depressive Disorder, Smoking

In brief

This study will assess whether varenicline (chantix) has antidepressant properties when used in addition to other psychiatric medication. It will also assess whether varenicline improves the inability to feel pleasure (i.e. anhedonia), and if it is well-tolerated when used with psychiatric medications. Enrolled patients will be assessed for improved mood, improved anhedonia, overall sense of health, side effects as well as tobacco use for 6-8 weeks. Medication will be provided free of charge.

Key facts

Study ID

NCT00525837

Run by

Butler Hospital

People needed

18

Starts

2007-09-01

Expected to finish

2008-03-01

Last updated by the study team

2018-11-28

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets DSM-IV symptoms criteria for a mood disorder including major depression [unipolar or bipolar], depressive disorder NOS, dysthymia, adjustment disorder with depressed mood, or substance-induced mood disorder.
• Failed to achieve full symptom remission with previous pharmacotherapy.
• Current tobacco users.
• Able to give written, informed consent.

You may not qualify if…

• Past adverse reaction to varenicline.
• Renal failure or dialysis.
• Current pregnancy or breastfeeding.

Where it is running

• Butler Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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