The Metabolic Effects of Short-term Walnut Consumption in Subjects With the Metabolic Syndrome

Completed · Not applicable

Conditions studied: Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease

In brief

Walnuts include many potentially beneficial micronutrients and phytochemicals, in this study we propose to examine the effects of walnuts independent of macronutrient content. The purpose of this proposal is to study in depth the short-term effects of walnut consumption in men and women with the metabolic syndrome. Study Aim 1: To investigate the effects of walnuts (48gms per day over 3 days) on insulin resistance in subjects with the metabolic syndrome. Study Aim 2: To investigate the effects of 48gms per day of walnuts over 3 days on lipids and inflammatory markers. Study Aim 3: To assess the possible mechanisms of the biological effects of short-term walnut consumption through assessment of adipokines, resting metabolic rate, gene expression in white blood cells and the effect of walnuts when consumed as part of a mixed meal, on glucose excursions, insulin secretion and the excretion of gut peptides and free fatty acids.

Key facts

Study ID

NCT00525629

Run by

Christos Mantzoros

People needed

40

Starts

2007-02-01

Expected to finish

2008-12-01

Last updated by the study team

2017-12-15

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Metabolic Syndrome is defined as follows:
• Central Obesity- for Europid men this is a waist circumference of > 94cm for women >80cm or BMI >30.
• Plus 2 of the following 4 factors
• Elevated triglycerides: > 150 mg/dL
• Reduced HDL cholesterol < 40 mg/dL in men and < 50 mg/dL in women.
• Raised diastolic blood pressure systolic BP > 130mmHg or diastolic BP > 85mmHg or treatment with antihypertensives.
• Raised fasting plasma glucose > 100mg/dL or previously diagnosed type II diabetes.

You may not qualify if…

• Subjects with diabetes requiring medication or insulin are excluded.
• Subjects with any medical condition or on any treatment, which would interfere with the study outcomes or would make participation potentially harmful such as pregnancy or breastfeeding, anemia, heart disease, stroke, malabsorption syndromes according to a detailed medical history.
• Present alcoholism or drug abuse or use of medications that could interfere with the study such as corticosteroids, growth hormone, antiretroviral therapy. These conditions will be screened for by a detailed history and systems review.
• Individuals with nut allergy are excluded.

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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