ANDES-AGI-1067 as a Novel Antidiabetic Agent Evaluation Study

Status unconfirmed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Diabetes

In brief

This double-blind, placebo-controlled, dose-finding study is designed to identify the lowest AGI-1067 dose that improves glycemic control as measured by HbA1c and fasting glucose in subjects with Type 2 diabetes mellitus. Glycemic control will be measured during a 6-month treatment period in subjects who are on 1 or no antidiabetic drugs

Key facts

Study ID

NCT00525577

Run by

AtheroGenics

People needed

1012

Starts

2007-08-01

Expected to finish

2008-09-01

Last updated by the study team

2008-02-06

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provide informed written consent prior to entry.
• Be male or female 18-75 years of age at the time of entry and have Type 2 diabetes for a minimum of 6 months prior to Screening 1 visit.
• Have an HbA1c level measured at the Screening 1 and Screening 2 visits with a minimum level at ≥7.5% for both visits, as determined by the core lab analysis.
• Be taking either 1 or no antidiabetic agents. If on an antidiabetic medication, it must be of the sulphonylurea, metformin, or glitazone class, and the dosage must have been stable for the last 3 months prior to the Screening 1 visit. Note that no combination medications (i.e., counted as more than 1 agent) will be permitted prior to Randomization and that the use of GLP mimetrics, DPPIV inhibitors, or colesevelam are not permitted (rescue medication will be allowed at 3 months).
• Subjects who are using hormone replacement therapy must have been on stable doses of their hormone replacement therapy for at least 3 months prior to the Screening 1 visit.
• Females must not be breast feeding or pregnant. If they are of child-bearing potential, they must be using a reliable method of birth control considered suitable by the Investigator. If on hormonal contraceptives for more than 6 months, subjects will be allowed to participate in the study provided that this therapy remains constant throughout the study and for a period of 2 months after the end of the study.

You may not qualify if…

• Have Type 1 diabetes or history of ketoacidosis determined by medical history
• Have an HbA1c of more than 10.5% or a fasting glucose of >240 mg/dL (13.3 mmol/L) at either the Screening 1 [Visit 1] or Screening 2 [Visit 2])
• Have a history of severe diabetic neuropathy including autonomic neuropathy, gastroparesis, or lower limb ulceration or amputation.
• Have a history of long-term therapy with insulin (>30 days) within the last year or >7 days within the last 3 months.
• Require parenteral corticosteroids or recurrent continuous oral corticosteroid treatment (>2 weeks) within the last 3 months.
• Use weight loss drugs (e.g., orlistat, sibutramine, phenylpropanolamine, phentermine, or similar prescription or over-the-counter medications) within 3 months of the Screening 1 visit or intentional weight loss of ≥4 kg in the previous 6 months.
• Have had a new antidiabetic medication added, or the dose of an existing antidiabetic medication changed, in the last 3 months prior to the Screening 1 visit.
• Have had a stroke, MI, coronary artery bypass graft (CABG), percutaneous transluminal coronary angioplasty (PTCA), or admission with unstable angina within the last 6 months prior to the Screening 1 visit.
• Have congestive heart failure New York Heart Association Class III or IV (Appendix B).
• Have taken any of the following drugs in 6 months prior to the Screening 1 visit: cholestyramine, colestid, cyclosporine, or isotretinoin.
• Have acute infections requiring parenteral antibiotic treatment within the last 3 months.
• Have uncontrolled hypertension (defined as systolic blood pressure >180 mmHg).
• Have platelets <100,000 K/cu mm (x 103/μL) at the Screening 1 visit.
• Have active liver disease or hepatic dysfunction (total bilirubin, aspartate aminotransferase [AST], alanine aminotransferase [ALT] >1.5 times upper limit of normal [ULN]) as determined by core lab analysis at either the Screening 1 visit or the Screening 2 visits.
• Subjects with long QT syndrome as evidence by a QTc at the Screening 1 visit of >460 msec in males or >480 msec in females or subjects taking and requiring continued therapy with antiarrhythmic medications such as sotalol, quinidine, dofetilide, amiodarone or other drugs known to significantly prolong the QT interval (this will not include drugs associated with minor effect on the QT interval of less than 15 msec.)
• Have known major chronic infection or major hematologic, renal, metabolic, gastrointestinal or endocrine dysfunction in the judgment of the Investigator (including diabetes mellitus too severe to allow the subject to safely participate in this study).
• Have had a life-threatening illness or any history of cancer or malignancy within the past 5 years (except for basal cell carcinoma).
• Have had surgery requiring inpatient admission within 30 days prior to the Screening 1 visit.
• Considered unreliable as a study participant based on the Investigator's (or designee's) knowledge of the subject (e.g., history of alcohol or other drug abuse, inability or unwillingness to adhere to the protocol, or psychosis).
• Have a history of intolerance or previous use of probucol within the last 5 years.
• Have participated in a previous study with AGI-1067.
• Have participated in any investigational drug study within 30 days prior to study entry, or expects to participate in any other investigational drug study during the course of ANDES.

Where it is running

• Diabetes and Glandular Disease — San Antonio, Texas, United States
• Clinic for the Internal Medicine-Clinical Center Banja Luka — Banja Luka, Bosnia and Herzegovina
• Center of Endocrinology, Metabology & Nutriology — Tbilisi, Georgia
• Diagnostic Services Ltd. — Tbilisi, Georgia
• Georgian Diabetes Center — Tbilisi, Georgia
• Healthy Life Center — Tbilisi, Georgia
• Institute of Cardiology — Tbilisi, Georgia
• Tbilisi Center of Endocrinology — Tbilisi, Georgia
• Tbilisi State Medical University Clinic #1 — Tbilisi, Georgia
• Second floor , Silver Brook Building, — Ahmedabad, India
• Shantiniketan Hospital — Ahmedabad, India
• Bangalore Diabetes — Bangalore, India
• Bhagwan Mahaveer Jain Hospital — Bangalore, India
• M.s. Ramaiah Memorial Hospital — Bangalore, India
• St. Johns Medical College and Hospital, — Bangalore, India
• Belgaum Diabetes Centre — Belagavi, India
• Dr. V Seshiah Diabetes Care and Research Institute — Chennai, India
• Madras Research Center — Chennai, India
• Sri Ramachandra Medical Centre — Chennai, India
• Mediciti Hospital, 5-9-22 — Hyderabaad, India
• Medwin Hospitals — Hyderabaad, India
• Sai's Endocrine and Growth Centre — Hyderabaad, India
• Diabetes, Thyroid and Endocrine — Jaipur, India
• Saytam Hospital and Research Centre — Jaipur, India
• Clinical Research Atlanta — Stockbridge, Georgia, United States

Full record on ClinicalTrials.gov

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