Outcomes Study of Hyperinsulinemic Glucose Control in Cardiac Surgery

Completed · Not applicable

Conditions studied: Cardiac Surgery

In brief

Patients undergoing cardiac surgery will be randomized into one of two groups. Group A will be administered insulin using the hyperinsulinemic-normoglycemic clamp to normalize blood glucose levels intra-operatively. Group B will be administered insulin at the standard of care levels established by the participating institution. Patients will be followed at 10 days, 15 days and one year post-operatively.

Key facts

Study ID

NCT00524472

Run by

The Cleveland Clinic

People needed

1439

Starts

2007-07-01

Expected to finish

2015-04-01

Last updated by the study team

2018-10-26

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-90 years old
• Scheduled for cardiac surgery requiring cardiopulmonary bypass

You may not qualify if…

• Off-pump surgical procedures
• Anticipated deep hypothermic circulatory arrest
• In available, baseline cardiac troponin I (>0.5 ng/L) or troponin T (> 0.1 ng/mL) levels (at RVH or CC, respectively)
• Any contraindications to the proposed interventions
• Active infection, including patients with endocarditis or infected pacemaker leads.
• Any infection requiring long- term antibiotics ( > 14 days)
• kidney disease requiring renal replacement therapy

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States
• Royal Victoria Hospital — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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