Research on Individualized Treatment for Alcoholism

Completed · Phase 2

Conditions studied: Alcohol Dependence

In brief

The purpose of this study was to compare the effects of two psychosocial treatments that differed in scope and intensity (Broad Spectrum Treatment and Motivational Enhancement Treatment) combined with 3 or 6 months of treatment with naltrexone on alcohol drinking behaviors in alcohol dependent patients.

Key facts

Study ID

NCT00523133

Run by

Indiana University

People needed

185

Starts

2000-09-01

Expected to finish

2005-07-01

Last updated by the study team

2007-08-31

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• men and women between the ages of 21-65
• current DSM-IV diagnosis of alcohol dependence
• abstinent for a minimum of 3 and maximum of 21 days prior to treatment initiation
• able to participate in an 18-month outpatient study
• live within a one hour or less commute to Fairbanks
• fluent in English
• women of child-bearing potential must have a negative pregnancy test and use effective contraceptive methods.
• score as contemplators or greater on the Readiness For Change Scale

You may not qualify if…

• severe hepatic disease (gGGT, SGOT or other liver functions greater than 4 times normal)
• opiate use (for any reason) in the last 14 days or a history of opioid dependence in the past year
• pregnant or lactating females or those unwilling to use birth control
• inability, according to the opinion of the interviewer, to follow medication instructions and safety precautions
• comorbid substance dependence (but not abuse) diagnosis in the past 6 months, excluding nicotine or marijuana dependence
• concomitant use of medications intended to decrease drinking (e.g. disulfiram)
• meeting current DSM criteria for bipolar disorder, schizophrenia, bulimia/anorexia, dementia, major depression

Where it is running

• University Hospital, Psychiatry Outpatient Clinic — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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