The Mental Activity and eXercise Trial for Seniors
Completed · Not applicable
Conditions studied: Cognitive Impairment
In brief
The primary objective of this study is to conduct a randomized, controlled trial to determine whether engaging in mental activity or exercise, either alone or in combination, improves cognitive function in non-demented, inactive older adults who self-report a recent decline in memory or thinking. In addition, we, the researchers at the University of California, San Francisco, plan to seek funding to follow subjects over time to determine whether these interventions are associated with changes in rate of cognitive decline or risk of dementia after the intervention period has ended.
Key facts
- Study ID
- NCT00522899
- Run by
- University of California, San Francisco
- People needed
- 126
- Starts
- 2007-08-01
- Expected to finish
- 2011-06-01
- Last updated by the study team
- 2012-04-09
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 64
- Self-report of recent decline in memory or thinking
- Low/no physical activity (<2 days/week for <30 minutes/session of moderate intensity activity over past 3 months)
- Low/no computer mental activity (<2 days/week for <30 minutes/session over past 3 months)
- Fluent in English
- Willingness to perform study activities
You may not qualify if…
- Evidence of dementia (based on self-report, physician diagnosis or score < 19 on Telephone Interview for Cognitive Status)
- Significant central nervous system disorder (Parkinson's disease, multiple sclerosis, ALS [Lou Gerig's disease])
- Major, current psychiatric disorder (major depressive disorder, schizophrenia, bipolar disorder, post-traumatic stress disorder, obsessive-compulsive disorder, psychiatric hospitalization in past 20 years)
- Major central nervous system event (stroke, transient ischemic attack/mini-stroke, seizure, or traumatic brain injury that has left a residual deficit)
- Significant heart disease (severe congestive heart failure, severe aortic stenosis, cardiac arrest, uncontrolled angina)
- Significant lung disease (requiring supplemental oxygen or oral or injected steroids)
- Other condition that would make participation potentially dangerous (cancer requiring treatment in past 3 years, severe arthritis, history of cardiac defibrillation, dialysis)
- Lack of physician approval
- Severe hearing or visual impairment
- History of learning disability
- Starting prescription medication to enhance cognitive function (e.g., memantine, aricept)
- Dependent in any basic activity of daily living (eating, dressing, bathing, toileting, getting out of bed/chair)
- History of alcohol abuse/heavy alcohol use
- History of drug abuse/heavy drug use
- Currently enrolled in another research study
- Fibromyalgia or tremor severe enough to prevent use of a computer mouse
- Planning to travel > 4 exercise class days during study period
- Behaviors during screening or baseline visit that, in the judgement of research staff, are likely to present significant problems (e.g., uncooperative, anger, inappropriate physical contact)
- Unable to perform neuropsychological evaluations
- Unable to complete consent process
Where it is running
- San Francisco Veterans Affairs Medical Center — San Francisco, California, United States
- University of California, San Francisco — San Francisco, California, United States
Full record on ClinicalTrials.gov
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