Buprenorphine for the Treatment of Neonatal Abstinence Syndrome
Completed · Phase 1
Conditions studied: Neonatal Abstinence Syndrome
In brief
Neonatal abstinence syndrome is a disease that affects children who were exposed to opioid drugs prior to birth. Commonly used treatments at present include morphine or tincture of opium. Buprenorphine is a drug used in adults to treat narcotic dependence, but has not been used for Neonatal Abstinence Syndrome. This trial is designed to see if the use of sublingual (under the tongue) buprenorphine is able to be used safely and easily in newborns with the neonatal abstinence syndrome. Secondary goals will be to see if treatment with buprenorphine is associated shorter stays in the hospital and fewer days of treatment than the use of standard therapy. Another secondary goal will be to understand buprenorphine concentration in the blood of babies treated with the drug (this is called "pharmacokinetics").
Key facts
- Study ID
- NCT00521248
- Run by
- Thomas Jefferson University
- People needed
- 60
- Starts
- 2004-04-01
- Expected to finish
- 2010-01-01
- Last updated by the study team
- 2017-01-12
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥ 37 weeks gestation
- exposure to opiates in utero
- demonstration of signs and symptoms of neonatal abstinence syndrome requiring treatment
You may not qualify if…
- major congenital malformations and/or intrauterine growth retardation
- medical illness requiring intensification of medical therapy
- concomitant benzodiazepine or severe alcohol abuse, self-report of regular use of alcohol or of benzodiazepines use in the past 30 days, and/or receipt of benzodiazepines by prescription (as determined by self-report or intake urine) by the mother during pregnancy,
- concomitant use of CYP 3A inhibitors (erythromycin, clarithromycin, ketoconazole, itraconazole, HIV protease inhibitors) or inducers (rifampin, carbamazepine, phenobarbital) prior to initiation of NAS treatment
- seizure activity or other neurologic abnormality
- breast feeding
- inability of mother to give informed consent due to co-morbid psychiatric diagnosis
- hypoglycemia requiring treatment with intravenous glucose
Where it is running
- Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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