Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)

Completed · Not applicable · Has a placebo group

Conditions studied: Migraine

In brief

The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain. Stimulation of the motor cortex with tDCS has already been shown to relieve pain in patients with other chronic pain syndromes, including traumatic spinal cord injury and fibromyalgia. Patients with migraine are usually extremely sensitive to pain. A treatment that targets the areas of the brain that are related to the experience of pain may also help decrease pain in patients with migraine. Pain control with this localized approach may help avoid the problems due to pain medications that affect all organs in the body. We hypothesize that 10 sessions of Transcranial Direct Current Stimulation (tDCS) applied over the area of the brain that controls pain and motor function will decrease pain and headache frequency in patients with migraine.

Key facts

Study ID

NCT00521196

Run by

Beth Israel Deaconess Medical Center

People needed

13

Starts

2007-07-01

Expected to finish

2012-01-13

Last updated by the study team

2017-03-21

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must be between 18 and 65 years of age.
• The diagnosis must meet the 2004 IHS criteria for migraine without aura, migraine with aura, or chronic migraine.
• The duration of the disease must be of at least one year.
• Subjects must have maintained their routine preventative medication consistently for at least two months (if applicable) prior to study initiation.

You may not qualify if…

• Patients with major depression with suicidal risk, as clinically defined.
• Patients with other known neuropsychiatric disorders.
• Patients with other chronic pain disorders
• History of substance abuse or dependence within the last six months
• Known brain metastasis
• History of neurological disorders (such as stroke)
• History of brain surgery
• Prior experience with tDCS
• Abnormal neurological examination, other than those pertaining to the signs of the condition studied in this protocol.
• Contraindication to tDCS: metallic hardware in the head or scalp: shrapnel, surgical clips, or fragments from welding

Where it is running

• Beth Israel Deaconess Medical Center: Berenson-Allen Center for Noninvasive Brain Stimulation — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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