Sunitinib Malate in Treating Patients With Iodine-Refractory Recurrent or Metastatic Thyroid Cancer

Completed · Phase 2

Conditions studied: Recurrent Thyroid Cancer, Stage IVA Follicular Thyroid Cancer, Stage IVA Papillary Thyroid Cancer, Stage IVB Follicular Thyroid Cancer, Stage IVB Papillary Thyroid Cancer, Stage IVC Follicular Thyroid Cancer, Stage IVC Papillary Thyroid Cancer, Thyroid Gland Medullary Carcinoma

In brief

This phase II trial studies how well giving sunitinib malate works in treating patients with iodine-refractory recurrent or metastatic thyroid cancer. Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor

Key facts

Study ID: NCT00519896
Run by: University of Washington
People needed: 35
Starts: 2007-07-01
Expected to finish: 2015-09-01
Last updated by the study team: 2017-04-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Histologically or cytologically proven metastatic WDTC or MTC
Evidence of refractoriness to iodine therapy for WDTC documented by a combination of imaging and thyroglobulin or by biopsy
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3
Evidence of fludeoxyglucose F 18 (FDG) PET avid metastatic tumors
Measurable disease by RECIST criteria
Resolution of all acute toxic effects of prior systemic therapy (including iodine therapy or chemotherapy), radiotherapy or surgical procedure to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 3.0 grade =< 1
Total serum bilirubin =< 1.5 x upper limit of normal (ULN) (patients with Gilbert's disease exempt)
Serum transaminases =< 2.5 x ULN or =< 5.0 X ULN if secondary to liver metastases
Serum creatinine =< 1.5 x ULN
Absolute neutrophil count (ANC) >= 1.5 X 10\^9/L
Platelets >= 100,000/uL
Hemoglobin >= 9.0 g/dL
Willingness and ability to comply with scheduled visits, treatment plans and laboratory tests and other study procedures
Male and female patients with reproductive potential must use an acceptable contraceptive method
Signed and dated informed consent document indicating that the patient has been informed of all the pertinent aspects of the trial prior to enrollment

You may not qualify if…

Concomitant treatment in another therapeutic clinical trial
ECOG performance status >= 3
Symptomatic, untreated, brain metastasis
Second primary malignancy that is clinically detectable or clinically significant at the time of consideration for study enrollment
Full-dose anticoagulation defined as:
Low molecular weight heparin use with the intent of full dose anticoagulation; example: enoxaparin 1.5 mg/kg daily or equivalent
Warfarin use to keep international normalized ratio (INR) greater than or equal to 2
History of gross hemoptysis (defined as bright red blood of at least 1/2 teaspoon or 2.5 mL per episode) within 3 months prior to study drug administration unless definitively treated with surgery or radiation
Any of the following within the 6 months prior to study drug administration: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, or pulmonary embolism; ongoing cardiac dysrhythmias of NCI CTCAE Version 3.0 grade >= 2
Type I Diabetes Mellitus; patients with Type II Diabetes Mellitus will be included as long as their glucose can be controlled between levels of 80 and 150 mg/dL
Uncontrolled Hypertension (> 150/100 mm Hg despite optimal medical therapy)
Major surgery or radiation therapy within 4 weeks of starting the study treatment
Other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that would impart, in the judgment of the investigator, excess risk associated with study participation or study drug administration, or which, in the judgment of the investigator, would make the patient inappropriate for entry into this study
Pregnancy or breast feeding

Where it is running

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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