Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium Diet

Completed · Phase 3 · Has a placebo group

Conditions studied: Hypertension

In brief

This study will measure the effects of different doses of aliskiren on kidney blood flow and function in healthy adults and determine how salt intake affects the response to aliskiren.

Key facts

Study ID

NCT00518765

Run by

Novartis

People needed

32

Starts

2005-10-01

Last updated by the study team

2010-10-06

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male and female subjects age 18 to 75 years of age included
• Strictly adhere to provided diet.

You may not qualify if…

• Symptomatic low blood pressure
• Prescription medications, including those for blood pressure control, birth control pills, and any other medication that could affect kidney function
• Over-the-counter medication 2 weeks before study start
• Clinically significant heart abnormalities.
• Previous history of allergy to the study drug or drugs similar to the study drug.
• Any surgical or medical condition which might significantly alter the action of a drug (for example, absorption, distribution, metabolism or excretion) or which may jeopardize the subject in case of participation in the study.
• Other protocol-defined inclusion/exclusion criteria apply

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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