Measuring Effectiveness in Sleep Apnea Surgery

Completed · Not applicable

Conditions studied: Obstructive Sleep Apnea

In brief

The goal of this research is to improve our understanding of the effectiveness of surgical OSA treatment by evaluating its impact on these health-related and functional outcomes and comparing these effects to the changes in respiratory physiology achieved after surgery. To achieve this goal, we will examine key health-related (C-reactive protein, homocysteine, leptin, the homeostasis model of insulin resistance, and heart rate variability) and functional (sleep-related quality of life and vigilance) measures among a surgical group of OSA patients who do not tolerate non-surgical treatment (positive airway pressure, PAP) and a comparison group of matched OSA patients who tolerate PAP.

Key facts

Study ID

NCT00518128

Run by

University of California, San Francisco

People needed

60

Starts

2007-07-01

Expected to finish

2011-06-01

Last updated by the study team

2012-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Pregnant women
• Primary snoring or mild OSA (apnea-hypopnea index < 15)
• Known neurologic, cardiac, hepatic, or renal disorder
• Acute illness or infection
• Co-existing sleep disorder other than primary snoring
• Unable to fast overnight prior to blood draw

Where it is running

• UCSF Department of Otolaryngology - Head and Neck Surgery — San Francisco, California, United States

Full record on ClinicalTrials.gov

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