A Multi-Center Study of MYOBLOC for the Treatment of Sialorrhea in Parkinson's Disease Patients

Completed · Phase 2 · Has a placebo group

Conditions studied: Drooling

In brief

To determine safety, tolerability and preliminary efficacy of intraglandular injections of MYOBLOC for the treatment of sialorrhea in Parkinsons' Disease patients

Key facts

Study ID

NCT00515437

Run by

Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC

People needed

54

Starts

2007-07-01

Expected to finish

2008-09-01

Last updated by the study team

2026-04-21

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Parkinsons' Disease patients with Sialorrhea for at least 3 months

You may not qualify if…

• Patients with non-idiopathic PD parkinsonism
• Patients previously exposed to botulinum toxins
• Patients with a history of aspiration pneumonia, moderate/severe choking and/or moderate/severe dysphagia
• Patients with prior salivary gland surgery

Where it is running

• Dr Virgilio Evidente — Scottsdale, Arizona, United States
• Dr. Ronald Ziman — Northridge, California, United States
• Dr. James Sutton — Oxnard, California, United States
• Dr. Olga Klepitskaya — Denver, Colorado, United States
• Dr. Fernando Pagan — Washington D.C., District of Columbia, United States
• Dr Hubert Fernandez — Gainesville, Florida, United States
• Dr. Alan Freeman — Atlanta, Georgia, United States
• Dr. Katie Kompoliti — Chicago, Illinois, United States
• Dr. Robert Rodnitzky — Iowa City, Iowa, United States
• Dr. Stephen Reich — Baltimore, Maryland, United States
• Dr. Brad Racette — St Louis, Missouri, United States
• Dr. Eric Molho — Albany, New York, United States
• Dr. Joseph Friedman — Warwick, Rhode Island, United States
• Dr. Vanessa Hinson — Charleston, South Carolina, United States
• Dr. Sam Kabbani — Knoxville, Tennessee, United States
• Dr. Madhavi Thomas — Dallas, Texas, United States
• Dr. Gordon Smith — Salt Lake City, Utah, United States
• Dr. Patrick Hogan — Tacoma, Washington, United States

Full record on ClinicalTrials.gov

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