Filgrastim-Mobilized Peripheral Blood Stem Cells for Allogeneic Transplantation With Unrelated Donors
Completed
Conditions studied: Healthy
In brief
Peripheral blood stem cells (PBSCs) collected following stimulation with filgrastim are commonly used for autologous hematopoietic transplants. PBSCs are also now being used for some syngeneic and allogeneic hematopoietic transplants involving HLA-matched sibling donors. However, many issues remain unanswered about the use of PBSCs for allogeneic transplants and the effects of filgrastim on healthy individuals. The purpose of this study is to determine the effectiveness of filgrastim stimulated PBSCs in hematopoietic cell transplants involving unrelated donors and to determine the effects of this donation process on unrelated stem cell donors.
Key facts
- Study ID
- NCT00511550
- Run by
- University of California, San Francisco
- People needed
- 15
- Starts
- 2005-08-01
- Expected to finish
- 2007-11-01
- Last updated by the study team
- 2008-03-05
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy adults
You may not qualify if…
- Pregnancy or uninterruptible breastfeeding.
- Sensitivity to filgrastim or to E. coli-derived recombinant protein products.
- History of autoimmune disorders, including rheumatic disease and thyroid disorders. Exception: As with bone marrow donations, donors with a history of thyroid disease who have undergone successful therapy may be suitable.
- History of deep vein thrombosis or pulmonary embolism.
- Thrombocytopenia <150 x 10(9)/L (<150,000/uL) at baseline evaluation.
- Current treatment with lithium. Drug interactions between filgrastim and lithium, which may potentiate the release of neutrophils, have not been full evaluated.
- Positive Hemoglobin-Solubility (e.g. SickleDex or equivalent) test.
- Donors receiving experimental therapy or investigational agents.
Where it is running
- University of California San Francisco Medical Center — San Francisco, California, United States
Full record on ClinicalTrials.gov
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