Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders

Completed

Conditions studied: CML, ALL, AML, Myelodysplasia, Lymphoma, Myeloproliferative Disorders

In brief

This study performs HLA matched stem cell transplantation from unrelated donors in adults who require stem cell transplantation but do not have a matched related donor available. The incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. This study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors.

Key facts

Study ID

NCT00511537

Run by

University of California, San Francisco

People needed

30

Starts

1999-01-01

Expected to finish

2009-06-01

Last updated by the study team

2013-08-02

Who can join

Age: 16 and older, up to 54. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >15 and <55
• Adequate renal function with serum creatinine <2.0 mg/dl
• Pulmonary diffusing capacity>50% of predicted
• Cardiac ejection fraction >40% as measured by radionuclide wall motion study or echocardiography
• Total bilirubin must be <2.5 mg/dl.
• Alkaline phosphatase and AST must be less than three times the upper limit of normal
• Negative serology for the human immunodeficiency virus
• Available HLA-matched donor
• Signed informed consent

You may not qualify if…

• No fully or single-antigen-mismatched sibling donor is available to donate stem cells
• No active liver disease.

Where it is running

• University of California San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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