Trial of Montelukast in Eosinophilic Esophagitis

Completed · Phase 1 · Has a placebo group

Conditions studied: Eosinophilic Esophagitis

In brief

Evaluate clinical effectiveness of oral montelukast compared to placebo on prevention of dysphagia and food impaction in patients with EE. Also evaluate tolerance and safety of oral montelukast in treatment of EE.

Key facts

Study ID

NCT00511316

Run by

Mayo Clinic

People needed

41

Starts

2007-08-01

Expected to finish

2015-09-01

Last updated by the study team

2015-11-03

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 years of age or older
• > 14 eosinophils / hpf on biopsies from mid esophagus within the 6 months.
• Abnormal dysphagia questionnaire (Question 1a yes, question 1c >/= mild and question 2 >/= less than once a week) prior to topical steroid treatment. This questionnaire has recently been validated.
• Normal dysphagia questionnaire after topical steroid treatment (Having an answer of no to question 1a: Have you had trouble swallowing, not associated with other cold symptoms? over the past two weeks since having completed the swallowed steroid treatment).

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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