NICardipine Neuroprotection in AortiC Surgery (NICNACS)

Stopped early · Phase 2

Conditions studied: Aortic Aneurysm, Thoracic

In brief

Objective The objective of this study is to discover whether an infusion of nicardipine is able to reduce the time taken to achieve electrocerebral silence (ECS) during cardiopulmonary bypass (CPB) for aortic surgery. Hypothesis By inhibiting cold-induced cerebral vasoconstriction, nicardipine will maintain cerebral blood flow and allow more rapid cooling of the brain during CPB. This will manifest as a reduction in the time taken to achieve ECS and also as a reduction in overall CPB time.

Key facts

Study ID

NCT00508118

Run by

Duke University

People needed

7

Starts

2008-01-01

Expected to finish

2008-04-01

Last updated by the study team

2014-08-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult (>18 years) patients at Duke University Medical Center (DUMC) presenting for elective aortic surgery scheduled to include a period of deep hypothermic circulatory arrest.

You may not qualify if…

• Failure to provide written informed consent
• Emergency operation
• Documented allergy to nicardipine

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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