Latent Tuberculosis Infection in Cancer Patients

Completed

Conditions studied: Advanced Cancer

In brief

Primary Objective: 1\. To evaluate the performance of the new T-SPOT.TB test and the conventional TST for screening of Latent Tuberculosis infections in patients with cancer and those undergoing Hematopoietic Stem Cell Transplant. Secondary Objectives: 1. To examine the factors associated with positive response to T-SPOT.TB and the TST (tuberculin skin test) in patients with anergy. 2. To determine the impact of immunosuppressive and antineoplastic therapy on the screening performance of T-SPOT.TB and the TST in cancer patients.

Key facts

Study ID

NCT00507754

Run by

M.D. Anderson Cancer Center

People needed

24

Starts

2007-06-01

Expected to finish

2011-05-01

Last updated by the study team

2011-09-26

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females.
• Patients who are receiving chemotherapy for hematologic malignancy and solid-organ cancer.
• Patients with a Hematopoietic stem cell transplantation (HSCT) history will be included after >1 year of transplantation.

You may not qualify if…

• Refusal of consent
• Individuals who, on the advice of the Primary or enrolling physician, may otherwise be at increased risk of an adverse reaction to venipuncture or tuberculin skin test administration.
• Lymphocytopenia (< 300 cells/microliter)
• Patients with known HIV infection.
• Patients with known active tuberculosis will not be included in this study.

Where it is running

• UT MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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