Etiology of Multiple Myeloma: A Case-Control Study
Status unconfirmed
Conditions studied: Multiple Myeloma
In brief
Objectives: The overall objective of this project is to identify risk factors associated with the development of multiple myeloma (MM) by integrating epidemiologic, clinical and molecular information. We plan to invite MDACC patients with MM, as well as controls, to participate in this investigative case-control study. Controls will be selected from friends and spouses who accompany patients to the various MDACC clinics and will be matched to the cases on age (±5 years), gender, and ethnicity. We will obtain demographic, risk factor and clinical information along with a blood and buccal sample from all cases and controls. This study could have implications for prevention and subsequent reduction in the incidence of multiple myeloma. Collecting blood and buccal samples will allow us to study the role genetic susceptibility plays in MM risk. The specific aims are: 1. To enroll and obtain, through self-administered questionnaires, risk factor information on all study participants to develop detailed demographic, epidemiologic, and behavioral profiles. This study will accrue 250 MM patients from MDACC and 250 healthy controls selected from friends and spouses who accompany patients to the MDACC clinics. Blood (25 ml) and buccal samples will be collected from all participants. 2. To identify risk factors associated with MM by integrating epidemiological, clinical and molecular information using a case-control approach. 3. To evaluate constitutional markers of genetic susceptibility as predictors of MM risk. Gene-environment interactions will be explored.
Key facts
- Study ID
- NCT00505999
- Run by
- M.D. Anderson Cancer Center
- People needed
- 140
- Starts
- 2006-07-01
- Expected to finish
- 2020-07-01
- Last updated by the study team
- 2020-01-02
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Cases: MDACC patients with confirmed MM who consent to complete a risk factor questionnaire and donate a 25ml blood specimen and a buccal sample.
- Controls: Friends or spouses of MDACC patients matched on age (± 5 years), sex and ethnicity who consent to complete a risk factor questionnaire and donate a 25 ml blood specimen and a buccal sample.
You may not qualify if…
- Cases: No exclusion criteria.
- Controls: Previous history of invasive cancer (excluding non-melanoma skin cancer)
Where it is running
- University of Texas MD Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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