Prospective Trial of Vaccine Responses in Childhood Cancer Survivors

Completed · Phase 2

Conditions studied: Childhood Cancer, Multiple Diseases

In brief

This study will look at your body's response to the new immunizations. We want to see how well they will protect you. Immunization is the same as vaccination. Our goal is to protect you as much as we can. We do not want you to have the measles, mumps, or whooping cough. We are doing the study because there is no standard way to re-immunize people after cancer treatments.

Key facts

Study ID

NCT00505063

Run by

Memorial Sloan Kettering Cancer Center

People needed

75

Starts

2007-07-10

Expected to finish

2025-06-11

Last updated by the study team

2026-07-29

Who can join

Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be < or less 18 years of age at cancer diagnosis
• Patient must be 3 to 24months following completion of chemotherapy for malignant disease.
• For patients <12 months following completion of therapy, CR must be documented within 3 months of enrollment.
• For patients >12 months, CR must be documented at approximately 12 months and then only as clinically indicated
• i. For patients with leukemia: bone marrow aspirate defined as <5% blasts, absence of cytogenetic abnormality by FISH or karyotype (if applicable) and no evidence of CSF involvement (if applicable) ii. For patients with solid tumors remission will be determined by appropriate radiologic scans, and other tests, including bone marrow aspirate and biopsies demonstrating absence of extrinsic cells and absence of specific FISH or cytogenetic abnormality (if applicable), iii. For patients with lymphoma, remission will be determined by bone marrow aspirate and biopsy, radiologic scans and other tests. Bone marrow will show <5% blasts, absence of cytogenetic abnormality by FISH or karyotype (if applicable), and flow cytometry (if lymphoma specific marker present) and absence of CNS disease by spinal fluid (if applicable)
• Patient may be of either gender and of any ethnic background
• Patients or their guardians must be able to understand the nature and risk of the proposed study and be able to sign consent.

You may not qualify if…

• Karnofsky score <70%.
• Female patients who are pregnant or lactating.
• Patients who have received an autologous or allogeneic HCT.
• Active uncontrolled bacterial or fungal infection.
• Patients who have a history of previous allergic reaction to vaccinations currently recommended by the ACIP.
• Patients on any immunosuppressive drugs.
• HIV-1,2 sero-positive patients.
• Patients or guardians not signing informed consent.
• Patients with prior allergic reaction to any vaccine component or to latex.
• Patients who have received Rituximab.

Where it is running

• Memorial Sloan-Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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