Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Stopped early · Phase 4 · Has a placebo group

Conditions studied: Healthy

In brief

This study involves 60 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a sequence of pictures on a screen, and presses a button if they remember seeing the picture before. While this is happening, the scanner will be capturing images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal and amygdala activation during the encoding and retrieval of memory,as measured by fMRI, will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala activities will be dissociable. This dissociation pattern will be different between the drugs propofol and thiopental.

Key facts

Study ID

NCT00504894

Run by

Weill Medical College of Cornell University

People needed

60

Starts

2007-03-01

Expected to finish

2013-11-01

Last updated by the study team

2021-07-15

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age b/w 18 and 50
• right-handed
• minimum of high school education
• fluent in English
• normal vocabulary

You may not qualify if…

• any significant medical/psychiatric comorbidity
• deficit in vision or hearing that would impede the study
• allergies to any of the study drugs, to soybeans, or eggs.
• history of head trauma
• family history of major psychiatric illness
• body mass index > 30 kg/m2
• claustrophobia
• prior exposure to IAPS pictures
• pregnancy
• permanent metal objects anywhere in the body
• a personal/family history of any porphyria

Where it is running

• Weill Cornell Medical College — New York, New York, United States

Full record on ClinicalTrials.gov

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