Transcranial Ultrasound in Clinical SONothrombolysis

Stopped early · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Acute Ischemic Stroke

In brief

This is a randomized, placebo controlled, parallel group dose escalation trial to evaluate the safety, tolerability, and activity of four sequential dose tiers of MRX-801 and ultrasound as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute ischemic stroke.

Key facts

Study ID

NCT00504842

Run by

ImaRx Therapeutics

People needed

72

Starts

2006-12-01

Expected to finish

2008-03-01

Last updated by the study team

2008-04-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute ischemic stroke
• Occlusion demonstrated by transcranial Doppler ultrasound
• Eligible for tPA

You may not qualify if…

• Right to left cardiac shunt
• Moderate to severe COPD
• Uncontrolled hypertension

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• Barrow Neurology Clinics at St. Joseph's Hospital — Phoenix, Arizona, United States
• Hoag Memorial Hospital — Newport Beach, California, United States
• California Pacific Medical Center — San Francisco, California, United States
• Colorado Neurological Institute — Englewood, Colorado, United States
• Christiana Care Health System — Newark, Delaware, United States
• University of Miami — Miami, Florida, United States
• St. Louis University School of Medicine — St Louis, Missouri, United States
• University of Rochester — Rochester, New York, United States
• Lehigh Valley Hospital — Allentown, Pennsylvania, United States
• Methodist Hospital Neurological Institute — Houston, Texas, United States
• University of Texas — Houston, Texas, United States
• Swedish Medical Center — Seattle, Washington, United States
• Bichat - Claude Bernard University Hospital and Medical School — Paris, France

Full record on ClinicalTrials.gov

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