Safety of Ovarian Stimulation With Letrozole and Gonadotropins in Breast Cancer Patients

Stopped early · Not applicable

Conditions studied: Breast Cancer

In brief

Breast cancer patients are commonly treated with drugs that eggs present in the ovary and may reduce their chance for getting pregnant. Their fertility can be preserved by stimulating their ovaries, collecting multiple eggs, fertilize them in the lab and freeze them. Ovarian stimulation increase their estrogen levels in blood.this may stimulate their cancer and increase chance for recurrence. If a medicine that prevent estrogen rise is used (letrozole), this may increase the safety of stimulation. In this study we compared ovarian stimulation in breast cancer patients using letrozole with those who did not undergo stimulation and showed that there is no increase risk for recurrence after a median follow up of 2 years

Key facts

Study ID

NCT00504699

Run by

New York Medical College

People needed

120

Starts

2002-01-01

Expected to finish

2018-03-01

Last updated by the study team

2018-03-29

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-45 years
• Biopsy proven breast cancer
• No prior chemotherapy or oophorectomy
• Regular menstrual cycles
• Normal basal FSH and estradiol

You may not qualify if…

• Stage 4 breast cancer

Where it is running

• IFPn — Valhalla, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.