Gene Polymorphisms and Symptoms in Lung Cancer Patients

Completed

Conditions studied: Lung Cancer

In brief

Primary Objectives: * Construct a prospective cohort of patients diagnosed with lung cancer and dispositioned for treatment and collect information on symptoms and symptom treatments at baseline and on follow-up. * Develop preliminary statistical models incorporating genetic data (which will be obtained from an existing protocol, CPN 91-001, Margaret Spitz), disease-related variables (e.g., stage of disease, location of tumor), clinical health status (e.g., performance status, comorbid conditions), and sociodemographic characteristics (e.g., age, sex, race) for predicting the risk of severe and persistent symptoms. Analytical aim: To determine if symptoms (e.g., fatigue, depression, lack of appetite) will differ in severity by IL-6 gene polymorphisms (-174G/C, -597G/A, -572G/C, -373An/Tn). This study (NIH-CA109043, Reyes-Gibby, 2004-2009) builds upon an NIH-funded (NIH-CA55769, Spitz, 2003-2008) study of the molecular epidemiology of lung cancer.

Key facts

Study ID

NCT00504374

Run by

M.D. Anderson Cancer Center

People needed

235

Starts

2006-06-13

Expected to finish

2017-04-27

Last updated by the study team

2019-06-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient has lung cancer and is being treated at M. D. Anderson.
• At least 18 years of age
• Currently living in the United States
• Enrolled in CPN 91-001 (Molecular epidemiology of lung cancer)
• English or Spanish speaking

You may not qualify if…

• Patient is unable to understand the intent of the study.

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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