Tracking of Respiratory-Induced Tumor Motion Using Implanted Fiducials

Completed · Not applicable

Conditions studied: Lung Cancer

In brief

Objectives: * To determine the safety of fiducial implantation. * To determine the extent/rate of migration of radio-opaque fiducials placed in lung tumors and adjacent normal tissue. * To compare real-time portal imaging-based fiducial tracking with measurement of three-dimensional motion by four-dimensional CT scanning to determine how many fiducials are needed to track a tumor. * To determine if intra-fractional lung tumor motion changes during a course of treatment, and when during the treatment this occurs. * To correlate the position of internal fiducials with the position of the external patient surface during respiration. * To quantify the residual motion of the clinical target volume during radiotherapy gated using external fiducials. * To verify the adequacy of the treatment portal margins in encompassing the residual motion of the clinical target volume. * To determine if radio-opaque fiducial placement adjacent to the trachea (which does not move) can reduce daily setup inaccuracies, and so spare normal tissue. * To determine the motion of hilar adenopathy (if any), and whether it correlates with motion of the primary tumor.

Key facts

Study ID

NCT00500513

Run by

M.D. Anderson Cancer Center

People needed

10

Starts

2004-04-01

Expected to finish

2011-12-01

Last updated by the study team

2013-02-01

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be undergoing radiation treatment.
• Planned course of radiation treatment must be greater than or equal to 6 weeks.
• The patient is able to tolerate bronchoscopy: a. Able to maintain oxygen saturation >95% on room air nasal cannula supplementation <5L/min, b. Can tolerate supine position without respiratory difficulties, c. Has normal hemodynamic parameters, d. Has normal coagulation profile
• The patient is a candidate for bronchogenic placement of seeds.
• The patient has an identifiable tumor on a CT scan.
• The patient has signed the consent form.

You may not qualify if…

• The patient has had previous thoracic surgery (e.g., lobectomy, pneumonectomy, tumor excision). Biopsy, mediastinoscopy, mastectomy are not exclusions.
• The patient has had previous radiation to the thorax.

Where it is running

• UT MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.