Evaluate the Efficacy &Safety of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD

Completed · Phase 3 · Has a placebo group

Conditions studied: ADHD

In brief

To assess the efficacy and safety of efficacy of MTS compared to placebo

Key facts

Study ID

NCT00499863

Run by

Noven Therapeutics

People needed

217

Starts

2007-07-01

Expected to finish

2008-05-01

Last updated by the study team

2017-04-26

Who can join

Age: 13 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject must meet criteria for a primary diagnosis of ADHD based on a detailed psychiatric evaluation.
• Subject must have a total score of ≥26 on the ADHD-RS-IV at the Baseline Visit (Visit 2).
• Subject must have a minimum level of intellectual functioning, as determined by an IQ (based on Kaufman Brief Intelligence Test [KBIT]) score of 80 or above.
• Subject has blood pressure measurements within the 95th percentile for age, gender, and height at Screening and Baseline.
• Subject is a male or female aged 13 17 years.
• Females must have a negative serum beta Human Chorionic Gonadotropin (HCG) pregnancy test at Screening and a negative urine pregnancy test at Baseline and agree to use acceptable contraceptives throughout the study period and for 30 days after the last dose of IP.

You may not qualify if…

• Subject has a current, controlled (requiring a restricted medication) or uncontrolled, with significant symptoms such as Post Traumatic Stress Disorder, psychosis, bipolar illness, pervasive developmental disorder, severe obsessive compulsive disorder, severe depressive or severe anxiety disorder.
• Subjects who, in the opinion of the Investigator, are acutely at risk for suicidal or violent behavior towards him/herself or others, or a history of a suicide attempt requiring medical intervention.
• Subject is overweight.
• Subject has a history of seizures during the last 2 years, a tic disorder, a current diagnosis and/or family history of Tourette's Disorder.
• Subject has Conduct Disorder.
• Subject has a positive urine drug or alcohol result at Screening (with the exception of subject's current stimulant therapy, if any).
• Subject has a history of alcohol or other substance abuse or dependence.
• Subject has taken an investigational drug within 30 days prior to screening.
• Subject has any abnormal thyroid function.
• Subject has any clinically significant laboratory abnormalities.
• Subject has severe allergic rhinitis, disability, or other condition that might confound the results of safety assessments administered in the study or that might increase risk to the subject. Mild, stable asthma is not exclusionary.
• The female subject is pregnant or lactating.
• Subject has any skin disease, or history of any chronic skin disease, skin cancer, skin manifestations of allergic disease, or other dermatologic conditions which would interfere with trial assessments or compromise subject safety (e.g. dermatitis, eczema or psoriasis).
• Subject has sensitive-skin syndrome (definition: subjects who often develop nonspecific skin irritancy reactions to bland materials) or has sensitivities to the ingredients in soaps, lotions, cosmetics or adhesives.
• Subject has clinical signs and symptoms of skin irritation (i.e., pruritus, burning, erythema) or scars or tattoos.

Where it is running

• Melmed Center — Scottsdale, Arizona, United States
• Bay Area Research Institute — Lafayette, California, United States
• Elite Clinical Trials Inc. — Wildomar, California, United States
• Sarkis Clinical Trials — Gainesville, Florida, United States
• Miami Research Associates — South Miami, Florida, United States
• Northwest Behavioral Research Ctr — Roswell, Georgia, United States
• Mountain West Clinical Trials, LLC — Eagle, Idaho, United States
• Vince and Associates Clinical Research — Overland Park, Kansas, United States
• Shire Clinical Research Site — Lexington, Kentucky, United States
• Four Rivers Clinical Research, Inc. — Paducah, Kentucky, United States
• Rochester Center for Behavioral Medicine — Rochester Hills, Michigan, United States
• Clinical Neurophysiology Services, PC — Troy, Michigan, United States
• CRI Worldwide — Clementon, New Jersey, United States
• Triangle Neuropsychiatry — Durham, North Carolina, United States
• Dakota Clinic/Innovis health — Fargo, North Dakota, United States
• Odyssey Research — Minot, North Dakota, United States
• University Hospitals Case Medical Center — Cleveland, Ohio, United States
• Oregon Center for Clinical Investigations, Inc. — Eugene, Oregon, United States
• OCCI, Inc — Portland, Oregon, United States
• Shire Clinical Research Site — Media, Pennsylvania, United States
• CRI Worldwide — Philadelphia, Pennsylvania, United States
• Rhode Island Hospital — Providence, Rhode Island, United States
• CNS Healthcare — Memphis, Tennessee, United States
• FutureSearch Trials — Austin, Texas, United States
• Claghorn-Lesem Research, Ltd. — Bellaire, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.